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For your patients with pulmonary arterial hypertension (PAH, WHO Group I)

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For your patients with pulmonary arterial hypertension (PAH, WHO Group I)

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Treat early with UPTRAVI®1

Evidence-based ESC/ERS Guidelines recommend UPTRAVI® (selexipag) at first follow-up for intermediate–low-risk patients.2* Learn more »

Treat early with UPTRAVI®1

Evidence-based ESC/ERS Guidelines recommend UPTRAVI® (selexipag) at first follow-up for intermediate–low-risk patients.2* Learn more »

Consistent and validated 
efficacy1,3,4

The largest PAH pivotal trial that included a broad range of patients with diverse background therapies and etiologies

View GRIPHON Trial

Demonstrated safety 
profile1,4

A consistent, long-term safety profile with no increased risk of major bleeding

View GRIPHON SAFETY

Patient-centric, oral BID dosing1,5

In GRIPHON, UPTRAVI® was proven effective regardless of the patients' personal maintenance dose

View UPTRAVI® DOSING

Support programs and educational resources: 
Start patients on UPTRAVI®

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*The 2022 ESC/ERS Guidelines recommend adding UPTRAVI® for patients without cardiopulmonary comorbidities who are at intermediate-low risk despite receiving ERA/PDE5i therapy. In these patients, switching from a PDE5i to riociguat may be considered. In patients who present as intermediate-high or high risk on oral therapies, also consider adding UPTRAVI® or switching from a PDE5i to riociguat if it is not feasible to add IV or SC prostacyclin analogs.2

BID=twice daily; ERA=endothelin receptor antagonist; ERS=European Respiratory Society; ESC=European Society of Cardiology; IP=prostacyclin; IV=intravenous; MOA=mechanism of action; PDE5i=phosphodiesterase type 5 inhibitor; SC=subcutaneous; WHO=World Health Organization.

References: 1. UPTRAVI® (selexipag) full Prescribing Information. Actelion Pharmaceuticals US, Inc. 2. Humbert M, Kovacs G, Hoeper MM, et al; ESC/ERS Scientific Document Group. 2022 ESC/ERS Guidelines for the diagnosis and treatment of pulmonary hypertension: the Task Force for the Diagnosis and Treatment of Pulmonary Hypertension of the European Society of Cardiology (ESC) and the European Respiratory Society (ERS). Eur Heart J. 2022‍;‍43‍(‍38‍)‍:‍3618‍-‍3731. 3. Data on file. Actelion Pharmaceuticals US, Inc. Length and Population Size of PAH Pivotal Trials Confirmation. June 2024. 4. Sitbon O, Channick R, Chin KM, et al; GRIPHON Investigators. Selexipag for the treatment of pulmonary arterial hypertension. N Engl J Med. 2015;373(26):2522-2533 and suppl. 5. Zeng C, Liu J, Zheng X, et al. Prostaglandin and prostaglandin receptors: present and future promising therapeutic targets for pulmonary arterial hypertension. Respir Res. 2023;24(1):263. doi:10.1186/s12931-023-02559-3