Questions?
REQUEST A MEDICAL SCIENCE LIAISON (MSL)
Questions?
REQUEST A MEDICAL SCIENCE LIAISON (MSL)
This site is intended for U.S.
healthcare professionals
You are now leaving UptraviHCP.com
Clicking CONTINUE below will take you to the selected site, the content for which Johnson & Johnson is not responsible and to which this Privacy Policy does not apply. We encourage you to read the Privacy Policy of every online service you visit.
Confirm that you wish to download the Veterans Affairs (VA) Patient Enrollment Form for UPTRAVI® (selexipag)
The following form is intended for use with patients who are eligible for VA benefits only.
STUDY DESIGN
GRIPHON Is the Largest PAH Pivotal Trial With the Longest Endpoint Evaluation Period of Any Prostacyclin Pathway Therapy1-3
- Multicenter, long-term, double-blind, placebo-controlled, parallel-group, event-driven, phase 3 trial1,4
Study Design1-3
Baseline Patient Characteristics1,5
- Mean age: 48 years
- Female: 80%
- Median time from PAH diagnosis in patients taking UPTRAVI®: 0.9 years
This article includes information that has not been approved by the Food and Drug Administration for UPTRAVI® (selexipag). Please see full Prescribing Information available on this website. Authors[s] of this article have received remuneration from Actelion Pharmaceuticals US, Inc., or its affiliates.
*Other=drugs and toxins (2%) and HIV (1%).
6MWD=6-minute walk distance; ERA=endothelin receptor antagonist; FC=Functional Class; GRIPHON=Prostacyclin (PGI2) Receptor Agonist In Pulmonary Arterial HypertensiON; HIV=human immunodeficiency virus; HPAH=heritable PAH; IPAH=idiopathic PAH; PAH-CHD=PAH associated with congenital heart disease with repaired shunts; PAH-CTD=PAH associated with connective tissue disease; PDE5i=phosphodiesterase type-5 inhibitor; WHO=World Health Organization.
1. UPTRAVI® (selexipag) full Prescribing Information. Actelion Pharmaceuticals US, Inc. 2. Sitbon O, Gomberg-Maitland M, Granton J, et al. Clinical trial design and new therapies for pulmonary arterial hypertension. Eur Respir J. 2019;53(1):1801908. doi:10.1183/13993003.01908-2018 3. Data on file. Actelion Pharmaceuticals US, Inc. Length and Population Size of PAH Pivotal Trials Confirmation. June 2024. 4. Sitbon O, Channick R, Chin KM, et al. Selexipag for the treatment of pulmonary hypertension. N Engl J Med. 2015;373:2522-2533 and suppl. 5. Data on file. Actelion Pharmaceuticals US, Inc. GRIPHON Baseline Characteristics Study Report.
