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GRIPHON Open-Label Extension

10 Years of Data: The Longest Follow-‍up Period of Any PAH Therapy1*

Estimates of survival for patients across GRIPHON and open-‍label extension studies (95% CI)2†

UPTRAVI® (selexipag) demonstrated consistent, long-term safety across GRIPHON (N=1156) and open-label extension1,3

These data are from long-term follow-up and an open-label extension study. These uncontrolled observations do not allow comparison with a control group not given UPTRAVI® and cannot be used to determine the long-term effect of UPTRAVI® on mortality.

At Year 10, 408 patients had been censored. Participant is said to be censored when information on time to event is not available due to loss to follow-‍up or non-occurrence of outcome event before the trial end.2,4

A long-term follow-up was conducted in patients who were treated with UPTRAVI® in the pivotal trial and OLE (N=‍574).2

*Based on published data.

Not adjusted for multiplicity.

CI=confidence interval; GRIPHON=Prostacyclin (PGI2) Receptor Agonist In Pulmonary Arterial HypertensiON.

References: 1. Galiè N, Gaine S, Channick R, et al. Long‍-‍term survival, safety and tolerability with selexipag in patients with pulmonary arterial hypertension: results from GRIPHON and its open‍-‍label extension. Adv Ther. 2022‍;‍39(‍1‍)‍:‍796‍-‍810. 2. Data on file. Actelion Pharmaceuticals US, Inc. Open-label Extension Survival Data. 2023. 3. UPTRAVI® (selexipag) full Prescribing Information. Actelion Pharmaceuticals US, Inc. 4. Prinja S, Gupta N, Verma R. Censoring in clinical trials: review of survival analysis techniques. Indian J Community Med. 2010;35(2):217-221.