GRIPHON Open-Label Extension

UPTRAVI—The Only Oral Prostacyclin Pathway Therapy With 7-year Survival Estimates1

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The information below is from the open-label extension of the GRIPHON trial.
View the GRIPHON pivotal data for context of the overall population.

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Patients enrolled into the pivotal trial (GRIPHON) were eligible to enter the corresponding long-term open-label extension study. In long-term follow-up of patients who were treated with UPTRAVI in the placebo-controlled study (N=574) and the open-label extension study (N=330, of 574), Kaplan-Meier estimates of survival at 1, 2, 5, and 7 years were 92%, 85%, 71%, and 63%, respectively. The median follow-up duration was 4.5 years, and the median exposure of UPTRAVI was 3.0 years.

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Overall survival Kaplan-Meier curve for patients randomized to UPTRAVI in GRIPHON and entered into the open-label extension study

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Data presented are Kaplan-Meier survival rate estimates (95% CI).